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KMID : 0043320180410020192
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Archives of Pharmacal Research
2018 Volume.41 No. 2 p.192 ~ p.195
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Phenolic amides from Tribulus terrestris and their inhibitory effects on nitric oxide production in RAW 264.7 cells
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Kim Hyung-Sik
Lee Jin-Woo
Jang Ha-Ri
Le Thi Phuong Linh
Kim Jun-Gu
Lee Moon-Soon
Hong Jin-Tae
Lee Mi-Kyeong
Hwang Bang-Yeon
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Abstract
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A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1?6, 8?11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC50 values of 18.7?49.4 μM.
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KEYWORD
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Tribulus terrestris, Zygophyllaceae, Phenolic amide, Nitric oxide production inhibitor
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